PRS7 Efficacy and Safety of Sildenafil Above 60 mg Daily in Pulmonary Arterial Hypertension Treatment - a Systematic Literature Review
Dry all parts with a clean paper towel.
Are There Any Downsides to Combination Therapy?
Remove the oral dosing syringe from the bottle adaptor by pulling straight up on the barrel of the oral dosing syringe. (See Figure F) Do not press on the plunger of the oral dosing syringe at this time. Put the tip of the oral dosing syringe into your or your child’s mouth and point it towards the inside of the cheek. Slowly push the plunger of the oral dosing syringe all the way down to give the entire dose. Do not squirt the medicine out quickly. Push the plunger back into the barrel. Store the oral dosing syringe with the REVATIO oral suspension bottle.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 90 + 6 Pills | 105.03€ 100.03€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 100mg | 360 + 10 Pills | 330.21€ 314.49€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ |
This Patient Information has been approved by the U.S. Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Sildenafil is a generic prescription drug that’s used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Sildenafil is available as the brand-name drugs Revatio and Viagra.
What is Sildenafil?
What are the possible side effects of REVATIO? REVATIO may cause serious side effects, including: See “What is the most important information I should know about REVATIO?” REVATIO may cause low blood pressure that last for a short time. If you take medicines to treat high blood pressure, your healthcare provider should monitor your blood pressure during treatment with REVATIO. Decreased eyesight or permanent loss of vision in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Most people who develop NAION have certain risk factors.
Drug Interactions
You can ask your healthcare provider if you have questions about risk factors for NAION. If you notice a sudden decrease or loss of vision in one or both eyes during treatment with REVATIO, contact your healthcare provider right away. Sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness. If you notice a sudden decrease or loss of hearing during treatment with REVATIO, contact your healthcare provider right away. In men, an erection that lasts for more than 4 hours (priapism).
If you take more than the recommended amount of Viagra
If you have an erection, with or without pain, that lasts more than 4 hours, contact your healthcare provider or get emergency medical help right away. A painful erection that lasts more than 6 hours must be treated right away or you can have lasting damage to your penis, including the inability to have erections. The most common side effects of REVATIO in adults include: getting red or hot in the face (flushing) The most common side effect of REVATIO in children is an erection that lasts for more than 4 hours (priapism). These are not all the possible side effects of REVATIO. Store REVATIO tablets at room temperature between 68°F to 77°F (20°C to 25°C). This article gives details on sildenafil’s price, including resources that could help lower its cost. a powder that’s mixed with water to form a liquid suspension (a type of liquid mixture), which is taken by mouth a liquid solution given by a healthcare professional as an intravenous (IV) injection Sildenafil is a generic medication that’s also available as the brand-name drugs Revatio and Viagra.
| Age Range | Percentage of Users | Common Conditions Treated |
|---|---|---|
| 40-60 | 55% | Erectile dysfunction |
| 60-75 | 35% | ED associated with aging |
| 75+ | 10% | Often with comorbidities |
For more details on sildenafil, see this in-depth article. Your cost may depend on your treatment plan, your insurance coverage, and the pharmacy you use. To find out how much you’ll pay for sildenafil, talk with your doctor, pharmacist, or insurance provider. Below are answers to some frequently asked questions about sildenafil and cost. No, the different strengths of sildenafil typically vary in cost.
How Much Is Too Much Sildenafil?
If you are giving REVATIO oral suspension to a child, make sure they are in an upright position before giving the medicine. Replace the cap on the bottle, leaving the bottle adaptor in place. Turn the cap in the direction of the arrow (clockwise) to close the bottle. Wash the oral dosing syringe after each use. Pull the plunger out of the barrel and rinse both parts with water. Each form of sildenafil comes in different strengths.
- Sildenafil 60mg may interact with blood pressure medications.
- Use with caution if you have a history of priapism.
- Blood tests may be required before starting treatment.
- Regular medical check-ups are recommended.
And both the strength and form of sildenafil you use can affect the drug’s cost.
- Common side effects include flushing and nasal congestion.
- Seek emergency help if experiencing prolonged erection.
- Do not use if you are taking nitrates.
- Alcohol consumption can decrease effectiveness.
The chart below shows the available forms and strengths of sildenafil. * This form is given by a healthcare professional during a hospital stay. Your doctor may prescribe a strength of sildenafil that isn’t available from the drug manufacturer.
- Sildenafil 60mg may cause headaches as a common side effect.
- Avoid grapefruit or grapefruit juice while on this medication.
- Consult a doctor before combining with other medications.
- Do not use if you have severe heart or liver problems.
For example, they might prescribe you 60 mg of sildenafil.
Contraindications for Revatio
Store mixed (reconstituted) REVATIO oral suspension below 86°F (30°C) or in a refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze mixed REVATIO oral suspension. Throw away (discard) any remaining REVATIO oral suspension 60 days after mixed by the pharmacist. See the “Discard after” date written on the bottle label. Keep REVATIO and all medicines out of the reach of children.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
General information about the safe and effective use of REVATIO. Do not use REVATIO for a condition for which it was not prescribed. Do not give REVATIO to other people, even if they have the same symptoms that you have. You can ask your healthcare provider or pharmacist for information about REVATIO that is written for health professionals. REVATIO tablets: anhydrous dibasic calcium phosphate, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, titanium dioxide, and triacetin REVATIO oral suspension: citric acid anhydrous, colloidal silicon dioxide anhydrous, grape flavor, sodium benzoate, sodium citrate dihydrate, sorbitol, sucralose, titanium dioxide, and xanthan gum REVATIO® (re-VAH-tee-oh) (sildenafil) oral suspension Read this Instructions for Use before you start taking REVATIO oral suspension or giving REVATIO oral suspension to your child and each time you get a refill.
Do the different strengths of sildenafil cost the same?
This information does not take the place of talking to buy pills sildenafil your healthcare provider about your or your child’s medical condition or treatment. Ask your healthcare provider or pharmacist to show you how to measure and take or give your child’s prescribed dose of REVATIO oral suspension. Your pharmacist will mix (reconstitute) REVATIO oral suspension before it is given to you. Do not take or give REVATIO oral suspension and contact your pharmacist if the medicine in the bottle is still a powder. Always use the oral dosing syringe that comes with REVATIO oral suspension. In this case, you may take three of the 20 mg tablets to form 60 mg. It’s important to note that the number of tablets you’re prescribed can also affect the price you pay for sildenafil. If you have other questions about how the different strengths of sildenafil vary in cost, talk with your doctor, pharmacist, or insurance provider. It’s also available in a brand-name form called Viagra.
What should I know about storage and disposal of this medication?
Especially tell your healthcare provider if you or your child take: See “What is the most important information I should know about REVATIO?” REVATIO contains sildenafil, which is the same medicine found in another medicine called VIAGRA®. VIAGRA is used for the treatment of erectile dysfunction. Do not take VIAGRA or other PDE-5 inhibitors during treatment with REVATIO. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Know the medicines you or your child take.
Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Keep a list of your or your child’s medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Take or give REVATIO exactly as your healthcare provider tells you. Your healthcare provider may change your or your child’s dose of REVATIO as needed. Do not change your dose or stop taking REVATIO without talking to your healthcare provider. REVATIO may be prescribed to you as REVATIO tablets or REVATIO oral suspension.
Therapies for Erectile Dysfunction
Take your prescribed dose of REVATIO tablets or oral suspension 3 times a day. See the detailed Instructions for Use that comes with REVATIO oral suspension for information on how to take or give REVATIO oral suspension. REVATIO oral suspension will be mixed for you by your pharmacist. Do not mix REVATIO oral suspension with other medicine or flavoring. If you or your child take too much REVATIO, call your healthcare provider or go to the nearest hospital emergency room right away. Brand-name drugs generally cost more than generic drugs.
What side effects can this medication cause?
If your carton does not come with an oral dosing syringe, contact your pharmacist. Do not take or give REVATIO oral suspension if the bottle adaptor is not in the bottle. If the bottle adaptor is not in the bottle, contact your pharmacist. REVATIO oral suspension should not be mixed with any other medicine or flavoring. Supplies you will need to take or give a dose of REVATIO oral suspension (See Figure A): 1 bottle of REVATIO oral suspension with pre-inserted bottle adaptor 1 oral dosing syringe (provided in the carton) Shake the bottle of REVATIO oral suspension for 10 seconds before each use.
Frequently asked questions
Open the bottle by pushing down on the cap and twisting it in the direction of the arrow (counter-clockwise). Fully push down (depress) the plunger of the oral dosing syringe. Then insert the tip of the oral dosing syringe into the bottle adaptor while holding the bottle upright, on a flat surface. Turn the bottle upside down while holding the oral dosing syringe in place. Slowly pull back the plunger of the oral dosing syringe until the bottom of the plunger is even with the mL marking on the syringe for your or your child’s prescribed dose.
Before taking sildenafil,
If your or your child’s dose of REVATIO oral suspension is more than 2 mL (20 mg), you will need to divide the dose. Follow the instructions given to you by your healthcare provider or pharmacist about how to prepare the divided dose. If you see air bubbles in the oral dosing syringe, slowly push the plunger all the way up so that REVATIO oral suspension flows back into the bottle and repeat Step 4. Turn the bottle back upright with the oral dosing syringe still in place. Place the bottle on a flat surface. For more information about the cost of sildenafil compared with Viagra, see the “Is sildenafil available as a brand-name drug?” section below.
| Parameter | Value | Notes |
|---|---|---|
| Absorption time | 30-120 minutes | Peak plasma levels typically in 60 min |
| Half-life | Approx. 4 hours | Duration varies by individual |
| Oral bioavailability | About 40% | Depends on food and other factors |